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Born in Chepstow, Monmouthshire, Wales. Son of William Owen, railway engineer, who named his son after Isambard Kingdom Brunel. Educated at King's School, Gloucester, and Rossall. Studied natural sciences at Downing College, Cambridge.
Student at St George's, ?-1875; junior appointments, assistant physician 1882-1894, physician 1894-1904, consulting physician 1905-1927. Dean of St George's Medical School 1884. Visiting physician at Atkinson Morley's Convalescent Home, Wimbledon.
Assistant physician at the Brompton Hospital, 1883. Involved in establishing the National University of Wales, and was appointed senior deputy chancellor 1894. Vice-dean of the faculty of medicine at London University 1901, principal of Armstrong College, Newcastle, vice-chancellor ar Bristol University 1909. Knighthood in 1902. Represented Bristol on the General Medical Council 1910-1925. Executor of the will of Prince Louis Lucien Bonaparte (1813-1891).
Married Ethel Holland-Thomas in 1905. They had two daughters. Died in Paris 14 Jan 1927.
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Sources
Royal College of Physicians; Wikipedia