Opened in 1880 as the Bolingbroke Self-Supporting Hospital and House in Sickness with 30 beds and an Accident and Emergency department, catering for working classes and middle classes as a voluntary hospital, with care provided for a fee.

The hospital was rebuilt, with the first phase completed in 1901. During the First World War the hospital received military casualties from the Third London Hospital. A new wing was opened in 1927. During the Second World War, the hospital joined the Emergency Medical Service, affiliated with St Thomas' Hospital. It was damaged by bombs in 1941 and 1944.

The hospital joined the NHS in 1948, under the control of the Battersea and Putney Group Hospital Management Committee, part of the South West Metropolitan Regional Hospital Board. New X-ray department was opened in 1957, and a new Coronary Care Unit in 1967. In 1974, the hospital came under the control of the Merton, Sutton and Wandsworth Area Health Authority, part of the South West Thames Regional Health Authority. The Accident and Emergency department was closed in 1974.

In the 1980s, the hospital began to focus on services for older people. In 1993, the hospital became part of the newly formed St George's Healthcare NHS Trust. In-patients were transferred from the hospital in 2005 due to fire safety concerns, and the hospital became a community hospital with out-patient clinics and healthcare services. The hospital closed in 2007, and the clinical services were transferred to St John's Therapy Centre.