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Born in Maidenhead. Studied at King's College, London, 1833, but transferred to St George's Hospital in 1834. MRCS 1839, FRCS 1844. He was (one of) the first surgical registrars at the hospital, and later curator of the museum and lecturer in physiology.
Assistant surgeon at King's College Hospital 1847. Surgeon to the Lock Hospital. Returned to St George's Hospital as assistant surgeon in 1861 or 1863; surgeon 1868, consulting surgeon 1878-1898
Received the Jacksonian Prize from the Royal College of Surgeons in 1849 for his dissertation on purulent deposits. Member of Council and Hunterian Professor at Royal College of Surgeons. Consulting surgeon to the Lock Hospital and Queen Charlotte's Hospital.
Specialisms: Syphilis. Published on venereal diseases, pathology and diseases of veins.
Married twice, with daughters and a son. Retired 1878. Lived at 9 Savile Row. Died at home in 61 Queensborough Terrace, Hyde Park, London on 11 Jun 1898. His son, Henry Lee, was also a Student at St George's Hospital Medical School (student no 5225)
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Royal College of Surgeons; Student register 1834 (No 3461)