Born in Liverpool, the son of merchant Thomas Pickering Pick. Educated at the Royal Institution School, Liverpool.
Student at St George's Hospital Medical School 1857. House surgeon 1863, surgical registrar and demonstrator of anatomy 1864-1866, curator of the museum 1866-1869. Assistant surgeon 1869-1878, surgeon 1878-1898, consulting surgeon 1898-1919. Visiting surgeon at Atkinson Morley's Convalescent Home, Wimbledon.
HM Inspector of Anatomy for England and Wales. Surgeon at the Belgrave Hospital, the Victoria Hospital for Children 1886-1891 and the Home for Incurables. Examiner in anatomy at the Royal College of Surgeons and the Court of Examiners in Surgery. Hunterian Professor of Surgery and Pathology 1894. Member of the Council at the RCS, vice-president 1898-1899.
Edited the 10th-16th editions of Gray's 'Anatomy'. Edited the 5th edition of the 'Treatise on Surgery, its Principles and Practice' by Timothy Holmes, 1888. Wrote 'Fractures and Dislocations, excluding Fractures of the Skull', 1885 and 'Surgery, a Treatise for Students and Practitioners', 1899 and published on the surgery of children's diseases and wounds.
Married Adeline Lawrence. Two of their sons became doctors. Retired to the Nook, Great Bookham, Surrey. Died on 6 Sep 1919